The Nobel season opens on Monday (Oct 4) with the pioneers of mRNA COVID-19 vaccines and immune system research tipped for the medicine prize, which kicks off a week of awards against the backdrop of the pandemic.
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Breakthroughs in breast cancer, new approaches to rheumatology treatments, as well as research into epigenetics, cell adhesion and antibiotic resistance are also believed to have good chances of winning, experts polled by AFP said.
Two names stand out in particular this year, given the ongoing pandemic: Hungary's Katalin Kariko and Drew Weissman of the United States, pioneers of messenger RNA (mRNA) vaccines and professors at the University of Pennsylvania.
Their discoveries, published in 2005, paved the way for the development of the Pfizer-BioNTech and Moderna vaccines, which have already been injected into more than a billion people worldwide.
The technology has also shown promising results for use against other diseases.
The creator of the prizes, Swedish dynamite inventor Alfred Nobel, laid out in his will that the awards should go to those who have conferred the "greatest benefit to humankind" - making the pair an obvious choice to some.
"It would be a mistake for the Nobel committee not to give the prize to the mRNA vaccine this year, even if it is a bit risky," said Ulrika Bjorksten, head of Swedish public radio's science section.