A surge of Omicron cases will push European health systems towards the brink, the World Health Organization's top official in the continent has warned.
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Hans Kluge said "another storm" was coming and governments should brace for significant increases in cases.
His warning came as several countries re-imposed social distancing restrictions.
Germany announced new post-Christmas rules including limits on parties.
"We cannot - and must not - close our eyes to this next wave which is beginning to loom over us," Germany's chancellor Olaf Scholz said on Tuesday, adding that "coronavirus doesn't take a Christmas break."
Meanwhile Portugal ordered bars and nightclubs to shut from 26 December.
UK Prime Minister Boris Johnson has ruled out any new restrictions for England before Christmas, but Scotland, Wales and Northern Ireland have all announced curbs on social mixing.
Omicron was first identified in southern Africa last month but has now spread around the globe.
It has been detected in at least 38 of the 53 countries in the WHO's European region - which includes Russia and Turkey - and is dominant in several, the organisation says.
"We can see another storm coming. Within weeks, Omicron will dominate in more countries of the region, pushing already stretched health systems further to the brink," said Mr Kluge, quoted by Reuters.
"The sheer volume of new Covid-19 infections could lead to more hospitalisations and widespread disruption to health systems and other critical services.
"Governments and authorities need to prepare our response systems for a significant surge."